Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Kltm1Yin
Name:	klotho; targeted mutation 1, Yo-ichi Nabeshima
MGI ID:	MGI:2684400
Synonyms:	kl-
Gene:	Kl  Location: Chr5:150876072-150917282 bp, + strand  Genetic Position: Chr5, 89.77 cM, cytoband G3
Alliance:	Kltm1Yin page

Germline Transmission:	Earliest citation of germline transmission: J:86859
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129

Allele Type:    Targeted (Null/knockout) Mutation:    Insertion   Mutation details: Exon 1 was disrupted by homologous recombination of a targeting vector. Protein was undetected in homozygous mutant mice. (J:86859)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

5 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Kl Mutation:	53 strains or lines available

Original:	J:86859 Tsujikawa H, et al., Klotho, a gene related to a syndrome resembling human premature aging, functions in a negative regulatory circuit of vitamin D endocrine system. Mol Endocrinol. 2003 Dec;17(12):2393-403
All:	6 reference(s)