Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Tumor data | Find Mice (IMSR) | References

Symbol: Clockm1Jt Name: clock circadian regulator; Clock MGI ID: MGI:1861634 Synonyms: Ck, Clockdelta19, Clockmut Gene: Clock  Location: Chr5:76357715-76452639 bp, - strand  Genetic Position: Chr5, 40.63 cM Alliance: Clockm1Jt page

Altered cell cycle progression in the secondary hair germ of hair follicles of Bmal1tm1Bra/Bmal1tm1Bra and Clockm1Jt/Clockm1Jt mice Show the 1 phenotype image(s) involving this allele.

Strain of Origin:

C57BL/6J

Allele Type:    Chemically induced (ENU) Mutation:    Single point mutation   Mutation details: ENU mutagenesis caused an A to T transversion at the third base position of the 5' splice donor site of intron 19. RT-PCR using primers for exon 15 and exon 21 detected shorter transcripts and no wild-type transcript in hypothalamus of homozygous mutant mice. Sequence analysis revealed that these shorter transcripts are missing exon 19. The authors predict the protein will be missing a 51 amino acid region within the carboxy terminus. (J:40364) Inheritance:    Semidominant

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	5 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	9 anatomical structure(s)

List all tumor models in MMHCdb carrying Clockm1Jt

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 3 strains available      Cell Lines: 0 lines available
Carrying any Clock Mutation:	101 strains or lines available

Original:	J:18005 Vitaterna MH, et al., Mutagenesis and mapping of a mouse gene, Clock, essential for circadian behavior. Science. 1994 Apr 29;264(5159):719-25
All:	173 reference(s)