Fbln5tm1Eno
Targeted Allele Detail
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Symbol: |
Fbln5tm1Eno |
Name: |
fibulin 5; targeted mutation 1, Eric N Olson |
MGI ID: |
MGI:2681517 |
Synonyms: |
C18-6, fbln5-, fibulin-5- |
Gene: |
Fbln5 Location: Chr12:101712824-101785314 bp, - strand Genetic Position: Chr12, 51.29 cM, cytoband F1
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Alliance: |
Fbln5tm1Eno page
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Vascular remodeling in Fbln5tm1Eno/Fbln5tm1Eno mice after 28 days of ligation
Show the 2 phenotype image(s) involving this allele.
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Germline Transmission: |
Earliest citation of germline transmission:
J:86754
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Parent Cell Line: |
SM1 (ES Cell)
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Strain of Origin: |
129S6/SvEvTac
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Allele Type: |
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Targeted (Null/knockout, Reporter) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: A cassette containing lacZ and neo was inserted at the first start codon, located in exon 1a. Deleted sequence included the coding region of exon 1a, intron 1, and the 5' untranslated region of exon 1b. The downstream start codon, located in exon 1b, was left intact. Protein was undetected by Western blot analysis of skin fibroblasts and vascular smooth muscle cells obtained from homozygous mutant mice.
(J:86754)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Fbln5 Mutation: |
35 strains or lines available
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Original: |
J:86754 Yanagisawa H, et al., Fibulin-5 is an elastin-binding protein essential for elastic fibre development in vivo. Nature. 2002 Jan 10;415(6868):168-71 |
All: |
19 reference(s) |
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