Summary | Mutation origin | Mutation description | Expression | Phenotypes | Tumor data | Find Mice (IMSR) | References

Symbol:	Ptentm2Ppp
Name:	phosphatase and tensin homolog; targeted mutation 2, Pier Paolo Pandolfi
MGI ID:	MGI:2679885
Synonyms:	Ptenhy, Ptenhypo
Gene:	Pten  Location: Chr19:32734977-32803560 bp, + strand  Genetic Position: Chr19, 28.14 cM
Alliance:	Ptentm2Ppp page

Germline Transmission:	Earliest citation of germline transmission: J:86212
Parent Cell Line:	CJ7 (ES Cell)
Strain of Origin:	129S1/Sv-Oca2+ Tyr+ Kitl+

Allele Type:    Targeted (Conditional ready, Hypomorph) Mutation:    Insertion   Mutation details: A hypomorphic allele was generated by the insertion of a floxed CMV-neo cassette into intron 3. A single loxP site was inserted into intron 5, thereby flanking exons 4 and 5 with loxP sites. (J:86212)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

4 anatomical structure(s)

List all tumor models in MMHCdb carrying Ptentm2Ppp

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pten Mutation:	81 strains or lines available

Original:	J:86212 Trotman LC, et al., Pten Dose Dictates Cancer Progression in the Prostate. PLoS Biol. 2003 Dec;1(3):385-96
All:	5 reference(s)