Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Tumor data | Find Mice (IMSR) | References

Symbol:	Apctm2Tno
Name:	APC, WNT signaling pathway regulator; targeted mutation 2, Tetsuo Noda
MGI ID:	MGI:2678005
Synonyms:	Apc1309, APC1309, APC 1309, Apcdelta1309
Gene:	Apc  Location: Chr18:34353977-34455605 bp, + strand  Genetic Position: Chr18, 18.53 cM
Alliance:	Apctm2Tno page

Germline Transmission:	Earliest citation of germline transmission: J:47857
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Humanized sequence, Null/knockout) Mutation:    Insertion   Mutation details: A frameshift mutation was introduced at codon 1309 via homolgous recombination, a most common germline mutation for human families susceptible to familial adenomatous polyposis coli (FAP). (J:47857) Inheritance:    Dominant

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

3 anatomical structure(s)

List all tumor models in MMHCdb carrying Apctm2Tno

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Apc Mutation:	154 strains or lines available

Original:	J:47857 Quesada CF, et al., Piroxicam and acarbose as chemopreventive agents for spontaneous intestinal adenomas in APC gene 1309 knockout mice. Jpn J Cancer Res. 1998 Apr;89(4):392-6
All:	7 reference(s)