Ncstntm1Jli
Targeted Allele Detail
|
|
| Symbol: |
Ncstntm1Jli |
| Name: |
nicastrin; targeted mutation 1, Jinhe Li |
| MGI ID: |
MGI:2675667 |
| Synonyms: |
Nicastrin- |
| Gene: |
Ncstn Location: Chr1:171893580-171910356 bp, - strand Genetic Position: Chr1, 79.54 cM
|
| Alliance: |
Ncstntm1Jli page
|
|
Abnormally segmented somite pairs in Ncstntm1Jli/Ncstntm1Jli mice
Show the 1 phenotype image(s) involving this allele.
|
|
|
| Germline Transmission: |
Earliest citation of germline transmission:
J:85205
|
| Parent Cell Line: |
Not Specified (ES Cell)
|
| Strain of Origin: |
129S5/SvEvBrd
|
|
| Allele Type: |
|
Targeted (Null/knockout, Reporter) |
| Mutations: |
|
Insertion, Intragenic deletion
|
| |
|
Mutation details: Beginning 3 nucleotides upstream of the translation initiation codon, 1530 bases were replaced with an IRESlacZ/MC1neo cassette. This replaced genomic sequence starting in exon 1 and extending through part of intron 2, deleting the first 63 amino acids of the protein product.
(J:85205)
|
|
|
View phenotypes and curated references for all genotypes (concatenated display).
|
| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
|
| Carrying any Ncstn Mutation: |
33 strains or lines available
|
|
| Original: |
J:85205 Li J, et al., Positive and negative regulation of the gamma-secretase activity by nicastrin in a murine model. J Biol Chem. 2003 Aug 29;278(35):33445-9 |
| All: |
1 reference(s) |
|
Analysis Tools
