Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Adrb2tm1Bkk
Name:	adrenergic receptor, beta 2; targeted mutation 1, Brian K Kobilka
MGI ID:	MGI:1859675
Synonyms:	Adrb2-, beta2AR-, Beta2-AR, Beta2-KO
Gene:	Adrb2  Location: Chr18:62310887-62313030 bp, - strand  Genetic Position: Chr18, 35.1 cM
Alliance:	Adrb2tm1Bkk page

Germline Transmission:	Earliest citation of germline transmission: J:55552
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutation:    Insertion   Mutation details: A neomycin selection cassette was inserted into the sequence encoding the fourth transmembrane segment. This mutation is predicted to eliminate expression of a functional receptor. Ligand binding experiments confirmed that no functional receptor was expressed in the lung of homozygous mice. (J:55552)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	104042 assay results 2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	9 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Adrb2 Mutation:	32 strains or lines available

Original:	J:55552 Chruscinski AJ, et al., Targeted disruption of the beta2 adrenergic receptor gene. J Biol Chem. 1999 Jun 11;274(24):16694-700
All:	155 reference(s)