Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Ezh2tm1Tara
Name:	enhancer of zeste 2 polycomb repressive complex 2 subunit; targeted mutation 1, Alexander Tarakhovsky
MGI ID:	MGI:2661097
Synonyms:	Ezh2F, Ezh2fl
Gene:	Ezh2  Location: Chr6:47507073-47572275 bp, - strand  Genetic Position: Chr6, 22.92 cM, cytoband B
Alliance:	Ezh2tm1Tara page

Germline Transmission:	Earliest citation of germline transmission: J:83216
Parent Cell Line:	E14.1 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: Four exons encoding the SET domain were left flanked by single loxP sites after the insertion of targeting vector and subsequent in vitro excision of a floxed neo cassette. (J:83216)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	80 assay results 15 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Ezh2 Mutation:	71 strains or lines available

Original:	J:83216 Su IH, et al., Ezh2 controls B cell development through histone H3 methylation and Igh rearrangement. Nat Immunol. 2003 Feb;4(2):124-31
All:	91 reference(s)