Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Thrbtm2Df
Name:	thyroid hormone receptor beta; targeted mutation 2, Douglas Forrest
MGI ID:	MGI:2657173
Synonyms:	Thrb2-
Gene:	Thrb  Location: Chr14:4431611-4809435 bp, - strand  Genetic Position: Chr14, 7.08 cM, cytoband A3
Alliance:	Thrbtm2Df page

Germline Transmission:	Earliest citation of germline transmission: J:66737
Parent Cell Line:	W9.5/W95 (ES Cell)
Strain of Origin:	129S1/Sv-Oca2+ Tyr+ Kitl+

Allele Type:    Targeted (Null/knockout, Reporter) Mutations:    Insertion, Intragenic deletion   Mutation details: The gene was disrupted by replacement of 165 bp of coding sequence with a lacZ-neo cassette via homologous recombination resulting in the fusion of the first 54 amino acids to the lacZ gene. Absence of gene expression in homozygous mutant animals was confirmed by RT-PCR analysis of RNA from the pituitary and eyes. (J:66737)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	2 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Thrb Mutation:	39 strains or lines available

Original:	J:66737 Ng L, et al., A thyroid hormone receptor that is required for the development of green cone photoreceptors. Nat Genet. 2001 Jan;27(1):94-8
All:	10 reference(s)