Summary | Mutation origin | Mutation description | Expression | Phenotypes | Tumor data | Find Mice (IMSR) | References

Symbol:	Brca1tm1Mak
Name:	breast cancer 1, early onset; targeted mutation 1, Tak Mak
MGI ID:	MGI:1858108
Synonyms:	Brca15-6
Gene:	Brca1  Location: Chr11:101379590-101442781 bp, - strand  Genetic Position: Chr11, 65.18 cM, cytoband D
Alliance:	Brca1tm1Mak page

Germline Transmission:	Earliest citation of germline transmission: J:33880
Parent Cell Line:	E14K (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion     Replacement of exons 5 and 6, encoding the zinc finger domain, with a neomycin cassette. (J:33880)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	17 assay results
In Structures Affected by this Mutation:	3 anatomical structure(s)

List all tumor models in MMHCdb carrying Brca1tm1Mak

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Brca1 Mutation:	113 strains or lines available

Original:	J:33880 Hakem R, et al., The tumor suppressor gene Brca1 is required for embryonic cellular proliferation in the mouse. Cell. 1996 Jun 28;85(7):1009-23
All:	2 reference(s)