Summary | Mutation origin | Mutation description | Phenotypes | Tumor data | Find Mice (IMSR) | References

Symbol:	Brca2tm2Hst
Name:	breast cancer 2, early onset; targeted mutation 2, Paul Hasty
MGI ID:	MGI:2653914
Synonyms:	brca2lex2
Gene:	Brca2  Location: Chr5:150446095-150493794 bp, + strand  Genetic Position: Chr5, 89.52 cM
Alliance:	Brca2tm2Hst page

Germline Transmission:	Earliest citation of germline transmission: J:82434
Parent Cell Line:	AB2.2 (ES Cell)
Strain of Origin:	129S7/SvEvBrd-Hprt1b-m2

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Most of exon 26 and all of exon 27 (coding nt 9265 through 9984) were replaced by a neomycin selection cassette inserted by homologous recombination. The deleted region included the RAD51-interacting domain. (J:49518, J:82434)

View phenotypes and curated references for all genotypes (concatenated display).

List all tumor models in MMHCdb carrying Brca2tm2Hst

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Brca2 Mutation:	132 strains or lines available

Original:	J:82434 Donoho G, et al., Deletion of Brca2 exon 27 causes hypersensitivity to DNA crosslinks, chromosomal instability, and reduced life span in mice. Genes Chromosomes Cancer. 2003 Apr;36(4):317-31
All:	3 reference(s)