Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Tnftm1Sek
Name:	tumor necrosis factor; targeted mutation 1, Kenji Sekikawa
MGI ID:	MGI:2653694
Synonyms:	TNF-, TNF-alpha-, TNFalpha-, TNFalpha KO
Gene:	Tnf  Location: Chr17:35418357-35420983 bp, - strand  Genetic Position: Chr17, 18.59 cM
Alliance:	Tnftm1Sek page

Germline Transmission:	Earliest citation of germline transmission: J:44841
Parent Cell Line:	TT2 (ES Cell)
Strain of Origin:	(C57BL/6NCrlj x CBA/JNCrlj)F1

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: All of exon 3 and a portion of exon 4 were replaced with a neomycin selection cassette inserted by homologous recombination. The deleted region encoded the DNA-binding domain (aa 84 through 174). (J:44841, J:92002)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

8 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Tnf Mutation:	46 strains or lines available

Original:	J:44841 Taniguchi T, et al., Failure of germinal center formation and impairment of response to endotoxin in tumor necrosis factor alpha-deficient mice. Lab Invest. 1997 Dec;77(6):647-58
All:	67 reference(s)