Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Kcnh2tm1Hjd
Name:	potassium voltage-gated channel, subfamily H (eag-related), member 2; targeted mutation 1, Henry J Duff
MGI ID:	MGI:2652959
Synonyms:	ERG1 B-
Gene:	Kcnh2  Location: Chr5:24524587-24556602 bp, - strand  Genetic Position: Chr5, 10.94 cM
Alliance:	Kcnh2tm1Hjd page

Germline Transmission:	Earliest citation of germline transmission: J:82249
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: An isoform specific mutation was generated by replacing the coding region of exon 1B with a floxed neomycin selection cassette. RT-PCR analysis verified that sequence upstream of the insertion, encoding the A isoform, was transcribed. Transcript encoding the B isoform was undected in homozygous mutant mice by RT-PCR analysis. (J:82249)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Kcnh2 Mutation:	43 strains or lines available

Original:	J:82249 Lees-Miller JP, et al., Selective knockout of mouse ERG1 B potassium channel eliminates I(Kr) in adult ventricular myocytes and elicits episodes of abrupt sinus bradycardia. Mol Cell Biol. 2003 Mar;23(6):1856-62
All:	1 reference(s)