Summary | Mutation origin | Mutation description | Expression | Find Mice (IMSR) | References

Symbol:	Egr2tm1Jchn
Name:	early growth response 2; targeted mutation 1, James Cohen
MGI ID:	MGI:2651549
Synonyms:	Egr2GFP(DT), Krox20GFP(DT)
Gene:	Egr2  Location: Chr10:67371305-67378018 bp, + strand  Genetic Position: Chr10, 34.96 cM, cytoband B5
Alliance:	Egr2tm1Jchn page

Germline Transmission:	Earliest citation of germline transmission: J:82071
Parent Cell Line:	CK35 (ES Cell)
Strain of Origin:	129S2/SvPas

Allele Type:    Targeted (Null/knockout, Reporter) Mutations:    Insertion, Intragenic deletion   Mutation details: The endogenous 5' coding region was replaced with sequence encoding EGFP, the diphtheria toxin A subunit (DT), and neo. The EGFP sequence was flanked by loxP sites and prevented the expression of DT. The expression pattern of EGFP recapitulated that of the endogenous gene. (J:82071)

In Mice Carrying this Mutation:

1 assay results

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Egr2 Mutation:	31 strains or lines available

Original:	J:82071 Vermeren M, et al., Integrity of developing spinal motor columns is regulated by neural crest derivatives at motor exit points. Neuron. 2003 Feb 6;37(3):403-15
All:	9 reference(s)