Summary | Mutation origin | Mutation description | Expression | Phenotypes | Tumor data | Find Mice (IMSR) | References

Symbol:	Smad4tm1Mak
Name:	SMAD family member 4; targeted mutation 1, Tak Mak
MGI ID:	MGI:1858049
Synonyms:	Smad4tm1Ari
Gene:	Smad4  Location: Chr18:73772080-73836851 bp, - strand  Genetic Position: Chr18, 49.51 cM
Alliance:	Smad4tm1Mak page

Germline Transmission:	Earliest citation of germline transmission: J:45399
Parent Cell Line:	E14K (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion     A neomycin resistance cassette replaced exon 8 and part of exon 9 of the gene. (J:45399)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	5 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

List all tumor models in MMHCdb carrying Smad4tm1Mak

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Smad4 Mutation:	43 strains or lines available

Original:	J:45399 Sirard C, et al., The tumor suppressor gene Smad4/Dpc4 is required for gastrulation and later for anterior development of the mouse embryo. Genes Dev. 1998 Jan 1;12(1):107-19
All:	6 reference(s)