Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Mettm4Cpo
Name:	met proto-oncogene; targeted mutation 4, Carola Ponzetta
MGI ID:	MGI:2450964
Synonyms:	Metgrb2neo+
Gene:	Met  Location: Chr6:17463799-17573979 bp, + strand  Genetic Position: Chr6, 7.83 cM, cytoband A2
Alliance:	Mettm4Cpo page

Germline Transmission:	Earliest citation of germline transmission: J:81793
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Humanized sequence) Mutation:    Nucleotide substitutions   Mutation details: A mutant human cDNA coding for the transmembrane and cytoplasmic domain of the receptor was inserted in-frame into mouse genomic sequences. The cDNA was followed by a floxed neomycin resistance cassette. A fusion protein consisting of the murine extracellular domain fused to the human transmembrane and cytoplasmic domain carrying the mutation Y1358N is produced from this allele. (J:81793)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:

1 assay results

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Met Mutation:	82 strains or lines available

Original:	J:81793 Ieraci A, et al., Viable hypomorphic signaling mutant of the Met receptor reveals a role for hepatocyte growth factor in postnatal cerebellar development. Proc Natl Acad Sci U S A. 2002 Nov 12;99(23):15200-5
All:	1 reference(s)