Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Lepob-2J
Name:	leptin; obese 2 Jackson
MGI ID:	MGI:1858048
Synonyms:	ob
Gene:	Lep  Location: Chr6:29060220-29073875 bp, + strand  Genetic Position: Chr6, 12.3 cM
Alliance:	Lepob-2J page

Strain of Origin:

SM/Ckc-Fbxw4Dac

Allele Type:    Spontaneous Mutation:    Transposon insertion   Mutation details: This allele is the result of an insertion of a full length early transposon, fusing exon 1 to the 3'LTR of the ETn. Northern analysis of adipose tissue RNA showed that the insertion provided alternative splice acceptor and polyadenylation sites producing fusion RNAs between the first exon and the retrovirus and precluding the expression of RNA from the coding sequence of Lep. (J:40727) Inheritance:    Recessive

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	1 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Lep Mutation:	19 strains or lines available

Original:	J:30778 Sweet HO, et al., Remutations at The Jackson Laboratory (Update to Mouse Genome 1993; 91:862-5 - J16313). Mouse Genome. 1995;93(4):1030-4
All:	3 reference(s)