Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Myf5tm2(Fgf6)Thbr
Name:	myogenic factor 5; targeted mutation 2, Thomas Braun
MGI ID:	MGI:2449208
Synonyms:	Myf-5FGF-6-ki
Gene:	Myf5  Location: Chr10:107318769-107321995 bp, - strand  Genetic Position: Chr10, 55.95 cM
Alliance:	Myf5tm2(Fgf6)Thbr page

Germline Transmission:	Earliest citation of germline transmission: J:63517
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Inserted expressed sequence, Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Deletion of all Myf5 coding sequences and replacement with an IRES-Fgf6 cDNA followed by a stop codon. A lox-P flanked neomycin cassette was also inserted downstream of FGF cDNA insertion site, but was removed via Cre-mediated recombination in ES cells prior to the generation of chimeric founder mice. This allele expresses an FGF6 transcript under the control of the Myf5 promoter. (J:63517)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Myf5 Mutation:	17 strains or lines available

Original:	J:63517 Kaul A, et al., Myf-5 revisited: loss of early myotome formation does not lead to a rib phenotype in homozygous Myf-5 mutant mice. Cell. 2000 Jul 7;102(1):17-9
All:	1 reference(s)