Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Mettm2Cpo
Name:	met proto-oncogene; targeted mutation 2, Carola Ponzetto
MGI ID:	MGI:1858021
Synonyms:	MetGrb2
Gene:	Met  Location: Chr6:17463799-17573979 bp, + strand  Genetic Position: Chr6, 7.83 cM, cytoband A2
Alliance:	Mettm2Cpo page

Germline Transmission:	Earliest citation of germline transmission: J:36244
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Humanized sequence, Inserted expressed sequence) Mutation:    Insertion   Mutation details: A mutant human cDNA coding for the transmembrane and cytoplasmic domain of the receptor was inserted in-frame into mouse genomic sequences. The cDNA was followed by a neomycin resistance cassette. A fusion protein consisting of the murine extracellular domain fused to the human transmembrane and cytoplasmic domain carrying the mutation N1358H is produced from this allele. (J:36244)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:

3 assay results

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Met Mutation:	82 strains or lines available

Original:	J:36244 Maina F, et al., Uncoupling of Grb2 from the Met receptor in vivo reveals complex roles in muscle development. Cell. 1996 Nov 1;87(3):531-42
All:	4 reference(s)