Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Spibtm1Mcs
Name:	Spi-B transcription factor (Spi-1/PU.1 related); targeted mutation 1, M Celeste Simon
MGI ID:	MGI:2448991
Synonyms:	Spi-B-
Gene:	Spib  Location: Chr7:44175417-44181495 bp, - strand  Genetic Position: Chr7, 28.83 cM
Alliance:	Spibtm1Mcs page

Germline Transmission:	Earliest citation of germline transmission: J:45245
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: The gene was disrupted by replacement of the DNA-binding domain-containing exon 6 and part of intron 5 with a PGK-neo cassette via homologous recombination. Northern blot analysis of homozygous mutant splenocyte RNA (using a full-length Spib cDNA probe) confirmed the absence of gene expression. (J:45245)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

4 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Spib Mutation:	19 strains or lines available

Original:	J:45245 Su GH, et al., Defective B cell receptor-mediated responses in mice lacking the Ets protein, Spi-B. EMBO J. 1997 Dec 1;16(23):7118-29
All:	22 reference(s)