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Spibtm1Mcs
Targeted Allele Detail
Nomenclature
Symbol: Spibtm1Mcs
Name: Spi-B transcription factor (Spi-1/PU.1 related); targeted mutation 1, M Celeste Simon
MGI ID: MGI:2448991
Synonyms: Spi-B-
Gene: Spib  Location: Chr7:44525993-44532071 bp, - strand  Genetic Position: Chr7, 28.83 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:45245
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe gene was disrupted by replacement of the DNA-binding domain-containing exon 6 and part of intron 5 with a PGK-neo cassette via homologous recombination. Northern blot analysis of homozygous mutant splenocyte RNA (using a full-length Spib cDNA probe) confirmed the absence of gene expression. (J:45245)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 4 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Spib Mutation:  11 strains or lines available
References
Original:  J:45245 Su GH, et al., Defective B cell receptor-mediated responses in mice lacking the Ets protein, Spi-B. EMBO J. 1997 Dec 1;16(23):7118-29
All:  18 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/15/2020
MGI 6.15
The Jackson Laboratory