Summary | Transgene origin | Transgene description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Sox2ysb
Name:	SRY (sex determining region Y)-box 2; yellow submarine
MGI ID:	MGI:2447996
Synonyms:	KM12
Gene:	Sox2  Location: Chr3:34704554-34706610 bp, + strand  Genetic Position: Chr3, 16.93 cM, cytoband A2-B
Alliance:	Sox2ysb page

Strain of Origin:

(CBA x C57BL/6)F1

Transgene Type:    Transgenic Mutation:    Intragenic deletion   Mutation details: This mutation arose as the result of the random insertion of an unrelated transgene. Molecular analysis indicated that two integration sites had occurred on chromosome 3 and a 20 kb deletion was also associated with one of these integration sites. Genetic noncomplementation tests with a targeted mutation indicated that this mutation is an allele of Sox2. Genomic PCR analysis showed that the coding region and nearby flanking DNA was intact in the mutants. Expression of the gene was severely reduced in the otocyst, in contrast to controls. This tissue specific loss is thought to be due to juxtaposition of the inserted transgenic reporter construct that interferes with the function of tissue-specific regulatory elements. (J:98458) Inheritance:    Recessive

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

8 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Sox2 Mutation:	56 strains or lines available

Original:	J:77358 Dong S, et al., Circling, deafness, and yellow coat displayed by yellow submarine (ysb) and light coat and circling (lcc) mice with mutations on chromosome 3. Genomics. 2002 Jun;79(6):777-84
All:	4 reference(s)