Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Lta/Tnftm1Fda
Name:	lymphotoxin A; targeted mutation 1, Francois Dautry
MGI ID:	MGI:2447728
Synonyms:	TNF-LT-
Gene:	Lta  Location: Chr17:35422141-35424327 bp, - strand  Genetic Position: Chr17, 18.59 cM
Alliance:	Lta/Tnftm1Fda page

Germline Transmission:	Earliest citation of germline transmission: J:39519
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intergenic deletion   Mutation details: The entire Lta gene and the majority of the Tnf gene (to codon 113 in exon 4) were replaced by a neomycin selection cassette inserted by homologous recombination. No transcript or truncated protein was detected by a variety of assays including Northern blot analysis of concanavalin A stimulated splenocytes and ELISA of macrophage colony supernatants. Tnf activity was undetected in LPS stimulated homozygous mutant mice. (J:39519)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Lta Mutation:	17 strains or lines available

Original:	J:39519 Amiot F, et al., Mice heterozygous for a deletion of the tumor necrosis factor-alpha and lymphotoxin-alpha genes: biological importance of a nonlinear response of tumor necrosis factor-alpha to gene dosage. Eur J Immunol. 1997 Apr;27(4):1035-42
All:	7 reference(s)