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Transgene Detail
Symbol: Tg(SFTPC-RAF1-BxB)1Urr
Name: transgene insertion 1, Ulf R Rapp
MGI ID: MGI:2447567
Synonyms: SP-C-c-raf-1-BxB, SP-C-craf-BxB, SP-C-craf BxB-23
Transgene: Tg(SFTPC-RAF1-BxB)1Urr  Location: unknown  
Strain of Origin:  (C57BL/6 x DBA/2)F1
Transgene Type:    Transgenic (Constitutively active, Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
Mutation detailsThe transgene is composed of a human SFTPC promoter, a human mutant RAF1 cDNA, and an SV40 small T antigen intron and polyadenylation signal. The mutant RAF1 sequence is deleted for the N-terminus and is constitutively active and highly transforming. 3.7 kb of human SFTPC promoter sequences was used to drive transgene expression in lung epithelium. The transgene is highly expressed in lungs as observed by Western blot analysis. The transgene is also weakly expressed in kidneys. (J:80895)
View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
2 independent transgenic lines were created.
Original:  J:80895 Kerkhoff E, et al., Lung-targeted expression of the c-Raf-1 kinase in transgenic mice exposes a novel oncogenic character of the wild-type protein. Cell Growth Differ. 2000 Apr;11(4):185-90
All:  15 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.19
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