Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Tumor data | Find Mice (IMSR) | References

Symbol: Apctm1Tno Name: APC, WNT signaling pathway regulator; targeted mutation 1, Tetsuo Noda MGI ID: MGI:1857966 Synonyms: 580S, Apc580s, Apc580S flox, Apcf, Apcfl, ApcloxP, Apclx Gene: Apc  Location: Chr18:34353977-34455605 bp, + strand  Genetic Position: Chr18, 18.53 cM Alliance: Apctm1Tno page

Anterior head defects during embryonic development in ApcMin/Apctm1Tno embryos and rescue of head defects by Ctnnb1tm4.1Wbm/Ctnnb1+ Show the 3 phenotype image(s) involving this allele.

Germline Transmission:	Earliest citation of germline transmission: J:43301
Parent Cell Line:	J1 (ES Cell)
Strain of Origin:	129S4/SvJae

Allele Type:    Targeted (Conditional ready, Hypomorph) Mutation:    Insertion   Mutation details: One loxP site was inserted into intron 13 and the other, with a PGK-neo cassette, into intron 14. Northern blot analysis revealed that RNA expression in the intestinal tract of homozygous mutants was about 30% of that in wild-type mice. Protein expression in the colon of homozygotes by immunohistochemistry was indistinguishable from that of wild-type mice. Western blot analysis of lysates from mouse embryo fibroblasts showed reduced expression of the protein. (J:43301, J:156864)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

12 anatomical structure(s)

List all tumor models in MMHCdb carrying Apctm1Tno

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 6 strains available      Cell Lines: 0 lines available
Carrying any Apc Mutation:	154 strains or lines available

Original:	J:43301 Shibata H, et al., Rapid colorectal adenoma formation initiated by conditional targeting of the Apc gene. Science. 1997 Oct 3;278(5335):120-3
All:	190 reference(s)