Summary | Mutation origin | Mutation description | Expression | Phenotypes | Tumor data | Find Mice (IMSR) | References

Symbol:	Mdm2tm1Glo
Name:	transformed mouse 3T3 cell double minute 2; targeted mutation 1, Guillermina Lozano
MGI ID:	MGI:1857945
Synonyms:	Mdm2-
Gene:	Mdm2  Location: Chr10:117524780-117546663 bp, - strand  Genetic Position: Chr10, 66.32 cM, cytoband C1-C3
Alliance:	Mdm2tm1Glo page

Germline Transmission:	Earliest citation of germline transmission: J:29810
Parent Cell Line:	AB1 (ES Cell)
Strain of Origin:	129S7/SvEvBrd-Hprt1+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A neomycin resistance cassette replaced two-thirds of the protein-coding sequences of the gene, including the acidic and zinc-finger domains, from amino acids 221-489. (J:29810)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	7 assay results
In Structures Affected by this Mutation:	6 anatomical structure(s)

List all tumor models in MMHCdb carrying Mdm2tm1Glo

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Mdm2 Mutation:	54 strains or lines available

Original:	J:29810 Montes de Oca Luna R, et al., Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53. Nature. 1995 Nov 9;378(6553):203-6
All:	45 reference(s)