Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Pitx2tm3Jfm
Name:	paired-like homeodomain transcription factor 2; targeted mutation 3, James F Martin
MGI ID:	MGI:2445425
Synonyms:	deltac neo
Gene:	Pitx2  Location: Chr3:128993527-129013240 bp, + strand  Genetic Position: Chr3, 57.84 cM
Alliance:	Pitx2tm3Jfm page

Germline Transmission:	Earliest citation of germline transmission: J:79853
Parent Cell Line:	AK7 (ES Cell)
Strain of Origin:	129S4/SvJaeSor

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exon 4 was replaced with a floxed neomycin selection cassette. Mice harboring this allele were crossed with transgenic mice expressing cre recombinase to generate an Pitx2tm3.1Jfm, which encodes isoforms a and b, but not the heart- and lung-specific c isoform. (J:79853)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pitx2 Mutation:	38 strains or lines available

Original:	J:79853 Liu C, et al., Pitx2c patterns anterior myocardium and aortic arch vessels and is required for local cell movement into atrioventricular cushions. Development. 2002 Nov;129(21):5081-91
All:	4 reference(s)