Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Msr1tm1Csk
Name:	macrophage scavenger receptor 1; targeted mutation 1, Chugai Pharmaceutical Co, Ltd
MGI ID:	MGI:1857874
Synonyms:	MSR-, Msr1-KO, Msr1tm1Kod, Scara1_, Scvrtm1, SR-, Sra-, SR-A-, SR-AI/II KO, SRAKO, SRKO
Gene:	Msr1  Location: Chr8:40034726-40095714 bp, - strand  Genetic Position: Chr8, 23.89 cM
Alliance:	Msr1tm1Csk page

Germline Transmission:	Earliest citation of germline transmission: J:39079
Parent Cell Line:	A3-1 (ES Cell)
Strain of Origin:	129X1/SvJ

Allele Type:    Targeted (Null/knockout) Mutation:    Insertion   Mutation details: A neomycin cassette was inserted into the EcoRI site in exon 4, which encodes the alpha helical coiled-coil structure essential for the formation of functional trimeric receptors. Protein was not detectable by immunostaining of liver sections from homozygous mutant animals. (J:39079)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:

2 assay results

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 4 strains available      Cell Lines: 0 lines available
Carrying any Msr1 Mutation:	10 strains or lines available

Original:	J:39079 Suzuki H, et al., A role for macrophage scavenger receptors in atherosclerosis and susceptibility to infection. Nature. 1997 Mar 20;386(6622):292-6
All:	136 reference(s)