Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Rxrbtm1Ipc
Name:	retinoid X receptor beta; targeted mutation 1, Pierre Chambon
MGI ID:	MGI:1857822
Synonyms:	Rarbeta-, RXRbeta-, Xbeta
Gene:	Rxrb  Location: Chr17:34250786-34257373 bp, + strand  Genetic Position: Chr17, 17.98 cM
Alliance:	Rxrbtm1Ipc page

Germline Transmission:	Earliest citation of germline transmission: J:30560
Parent Cell Line:	D3 (ES Cell)
Strain of Origin:	129S2/SvPas

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Genomic sequences encoding the DNA-binding domain in exons 3 and 4 were replaced by a neomycin cassette. RT-PCR analysis on total RNA derived from several tissues of homozygous mice revealed that transcripts corresponding to exon 2 as well as exons 5-9 were present at low levels in homozygous mice. The authors do not rule out the possiblility that some mutant protein could be expressed in homozygotes. (J:30560)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	9 assay results
In Structures Affected by this Mutation:	3 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Rxrb Mutation:	26 strains or lines available

Original:	J:30560 Kastner P, et al., Abnormal spermatogenesis in RXR beta mutant mice. Genes Dev. 1996 Jan 1;10(1):80-92
All:	13 reference(s)