Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Otx2tm1Sia
Name:	orthodenticle homeobox 2; targeted mutation 1, Shinichi Aizawa
MGI ID:	MGI:1857543
Synonyms:	Otx2-
Gene:	Otx2  Location: Chr14:48894238-48905101 bp, - strand  Genetic Position: Chr14, 25.36 cM
Alliance:	Otx2tm1Sia page

Germline Transmission:	Earliest citation of germline transmission: J:29682
Parent Cell Line:	TT2 (ES Cell)
Strain of Origin:	(C57BL/6NCrlj x CBA/JNCrlj)F1

Allele Type:    Targeted (Null/knockout) Mutation:    Insertion     A neomycin resistance cassette was inserted into sequences encoding the homeobox domain. (J:29682, J:74631)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	220 assay results
In Structures Affected by this Mutation:	51 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Otx2 Mutation:	50 strains or lines available

Original:	J:29682 Matsuo I, et al., Mouse Otx2 functions in the formation and patterning of rostral head. Genes Dev. 1995 Nov 1;9(21):2646-58
All:	17 reference(s)