Summary | Mutation origin | Mutation description | Expression | Phenotypes | Tumor data | Find Mice (IMSR) | References

Symbol:	Mdm2tm1Bay
Name:	transformed mouse 3T3 cell double minute 2; targeted mutation 1, Baylor College of Medicine
MGI ID:	MGI:1857463
Synonyms:	Mdm2-, Mdm2delta7-12, mdm2ml
Gene:	Mdm2  Location: Chr10:117524780-117546663 bp, - strand  Genetic Position: Chr10, 66.32 cM, cytoband C1-C3
Alliance:	Mdm2tm1Bay page

Germline Transmission:	Earliest citation of germline transmission: J:29811
Parent Cell Line:	AB2.1 (ES Cell)
Strain of Origin:	129S7/SvEvBrd-Hprt1b-m2

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: An hprt reporter replaced a 7.1 kb fragment of the gene encompassing all of exons 7 through 11 and a portion of exon 12. The deleted region encoded all of the putative transcription function motifs of the protein. (J:29811, J:81065)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	2 assay results
In Structures Affected by this Mutation:	4 anatomical structure(s)

List all tumor models in MMHCdb carrying Mdm2tm1Bay

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Mdm2 Mutation:	54 strains or lines available

Original:	J:29811 Jones SN, et al., Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53. Nature. 1995 Nov 9;378(6553):206-8
All:	15 reference(s)