Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Srd5a1tm1Mahe
Name:	steroid 5 alpha-reductase 1; targeted mutation 1, Mala Mahendroo
MGI ID:	MGI:1857454
Synonyms:	5alphaRKO, Srd5a1-
Gene:	Srd5a1  Location: Chr13:69721568-69759561 bp, - strand  Genetic Position: Chr13, 35.55 cM
Alliance:	Srd5a1tm1Mahe page

Germline Transmission:	Earliest citation of germline transmission: J:32217
Parent Cell Line:	JH1 (ES Cell)
Strain of Origin:	129S7/SvEvBrd

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A region encompassing promoter region and the a 3' portion of exon 1, encoding thr first 36 amino acids, was replaced by a neomycin selection cassette. Northern blot analysis of total RNA isolated from several organs showed an absence of transcript in homozygous mutant mice. (J:32217)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Srd5a1 Mutation:	11 strains or lines available

Original:	J:32217 Mahendroo MS, et al., 5 alpha-reduced androgens play a key role in murine parturition. Mol Endocrinol. 1996 Apr;10(4):380-92
All:	19 reference(s)