Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Hbbtm1Unc
Name:	hemoglobin beta chain complex; targeted mutation 1, University of North Carolina
MGI ID:	MGI:1857179
Synonyms:	Hbbth2
Gene:	Hbb  Location: unknown  Genetic Position: Chr7, Syntenic

Germline Transmission:	Earliest citation of germline transmission: J:4932
Parent Cell Line:	E14TG2a (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutation:    Insertion   Mutation details: A neomycin resistance cassette was inserted into exon 2 of the beta1 gene. No protein for the targeted gene was detected via cellulose electrophoresis of hemoglobin from homozygous mutant mice. (J:4932)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Hbb Mutation:	47 strains or lines available

Original:	J:4932 Shehee WR, et al., Lethal thalassemia after insertional disruption of the mouse major adult beta-globin gene. Proc Natl Acad Sci U S A. 1993 Apr 15;90(8):3177-81
All:	2 reference(s)