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Fostm1Pa
Targeted Allele Detail
Nomenclature
Symbol: Fostm1Pa
Name: FBJ osteosarcoma oncogene; targeted mutation 1, Virginia E Papaioannou
MGI ID: MGI:1857171
Synonyms: c-fos-
Gene: Fos  Location: Chr12:85473901-85477269 bp, + strand  Genetic Position: Chr12, 39.7 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:3233
Parent Cell Line:  PJ5 (ES Cell)
Strain of Origin:  129X1/SvJ
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsExon 1 was disrupted by the insertion of a neomycin selection cassette. Northern blot analysis showed an absence of transcript in homozygous mutant mice. (J:70953)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 12 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Fos Mutation:  28 strains or lines available
References
Original:  J:3233 Johnson RS, et al., Pleiotropic effects of a null mutation in the c-fos proto-oncogene. Cell. 1992 Nov 13;71(4):577-86
All:  29 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/15/2019
MGI 6.14
The Jackson Laboratory