Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol: Kdrtm1Jrt Name: kinase insert domain protein receptor; targeted mutation 1, Janet Rossant MGI ID: MGI:1857168 Synonyms: flk-1-, Flk1-, flk-1/lacZ, Flk1lacZ, Flk1lacZ, Flk1-lacZ neo-in, flk.lacZ, VEGFR-2-, Vegfr2lacZ Gene: Kdr  Location: Chr5:76093487-76139118 bp, - strand  Genetic Position: Chr5, 40.23 cM Alliance: Kdrtm1Jrt page

Suppression of of extraretinal vascular outgrowth in ischemic Kdrtm1.1Jamb/Kdrtm1Jrt Tg(CAG-cre/Esr1*)1Egwa/0 retinas Show the 3 phenotype image(s) involving this allele.

Germline Transmission:	Earliest citation of germline transmission: J:26846
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout, Reporter) Mutations:    Insertion, Intragenic deletion   Mutation details: Insertion of an in-frame lacZ gene and a loxP site flanked neomycin resistance gene cassette replaced the translated portion of the first coding exon and the proximal part of the next intron, and placed lacZ under the transcriptional control of the endogenous promoter. Neither RT-PCR using total RNA nor Western blot analysis using a carboxy terminal antibody detected gene expression in E8.5 homozygous mutant embryos. (J:26846)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	421 assay results
In Structures Affected by this Mutation:	7 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Kdr Mutation:	71 strains or lines available

Original:	J:26846 Shalaby F, et al., Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice. Nature. 1995 Jul 6;376(6535):62-6
All:	79 reference(s)