Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol: Bmp4tm1Blh Name: bone morphogenetic protein 4; targeted mutation 1, Brigid L Hogan MGI ID: MGI:1857137 Synonyms: Bmp4-, Bmp4delta, Bmp4tm1, Bmp-4tm1blh Gene: Bmp4  Location: Chr14:46620982-46628126 bp, - strand  Genetic Position: Chr14, 23.95 cM Alliance: Bmp4tm1Blh page

Anterior eye segment abnormalities in Bmp4tm1Blh/Bmp4+ mice Show the 2 phenotype image(s) involving this allele.

Germline Transmission:	Earliest citation of germline transmission: J:28717
Parent Cell Line:	D3 (ES Cell)
Strain of Origin:	129S2/SvPas

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A neomycin selection cassette replaced a genomic fragment containing all of the coding sequence of the gene after the seventh codon of exon 1. An oligonucleotide encoding a stop codon in all three reading frames was also inserted into exon 2. (J:28717)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	90 assay results
In Structures Affected by this Mutation:	40 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Bmp4 Mutation:	21 strains or lines available

Original:	J:28717 Winnier G, et al., Bone morphogenetic protein-4 is required for mesoderm formation and patterning in the mouse. Genes Dev. 1995 Sep 1;9(17):2105-16
All:	43 reference(s)