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Phenotypes Associated with This Genotype
Genotype
MGI:8161059
Allelic
Composition		 Tafa5tm1a(KOMP)Wtsi/Tafa5+
Tg(APPswe,PSEN1dE9)85Dbo/0
Genetic
Background		 B6.Cg-Tg(APPswe,PSEN1dE9)85Dbo Tafa5tm1a(KOMP)Wtsi
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tafa5tm1a(KOMP)Wtsi mutation (0 available); any Tafa5 mutation (13 available)
Tg(APPswe,PSEN1dE9)85Dbo mutation (9 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
extended life span ( J:360724 )
• mice exhibit an extended lifespan compared to Tg(APPswe,PSEN1dE9)85Dbo/0 mice, with survival rate beginning to decline at approximately 14 weeks of age compared to 8 weeks of age in Tg(APPswe,PSEN1dE9)85Dbo/0 mice and 65% of mice survive to 45 weeks compared to 40% of Tg(APPswe,PSEN1dE9)85Dbo/0 mice

nervous system
amyloid beta deposits ( J:360724 )
• mice exhibit a lower amyloid beta plaque density than single Tg(APPswe,PSEN1dE9)85Dbo/0 mice

homeostasis/metabolism
amyloid beta deposits ( J:360724 )
• mice exhibit a lower amyloid beta plaque density than single Tg(APPswe,PSEN1dE9)85Dbo/0 mice

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
10/13/2026
MGI 6.29 		The Jackson Laboratory