Phenotypes Associated with This Genotype

Genotype
MGI:8159416

• Allelic Composition: Lgr5^{tm3(cre/ERT2)Cle}/Lgr5⁺; Gt(ROSA)26Sor^{tm9(CAG-tdTomato)Hze}/Gt(ROSA)26Sor⁺
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NCrl

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

digestive/alimentary system

impaired intestine regeneration ( J:280699 )

• when mice are fed with a glucose-supplemented chow diet for 2 weeks and treated with TAM prior to radiation-induced intestinal injury, the ability of ISCs to generate tdTomato+ labeled progeny is reduced by 2-fold while the overall number of surviving intact jejunal crypts is significantly decreased at 3 days post-radiation

• a single oral bolus of beta-hydroxybutyrate (beta-OHB) 16 h prior to irradiation rescues these functional deficits

homeostasis/metabolism

abnormal response to radiation ( J:280699 )

• when mice are fed with a glucose-supplemented chow diet for 2 weeks and treated with TAM prior to radiation-induced intestinal injury, the ability of intestinal stem cells (ISCs) to generate tdTomato+ labeled progeny is reduced by 2-fold while the overall number of surviving intact jejunal crypts is significantly decreased at 3 days post-radiation

• a single oral bolus of beta-hydroxybutyrate (beta-OHB) 16 h prior to irradiation rescues these functional deficits