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Phenotypes Associated with This Genotype
Genotype
MGI:7861681
Allelic
Composition		 Wwtr1tm1.2Hmc/Wwtr1tm1.2Hmc
Yap1tm1.2Hmc/Yap1+
Tg(Myh11-cre,-EGFP)2Mik/0
Genetic
Background		 involves: 129 * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Myh11-cre,-EGFP)2Mik mutation (1 available)
Wwtr1tm1.2Hmc mutation (2 available); any Wwtr1 mutation (26 available)
Yap1tm1.2Hmc mutation (1 available); any Yap1 mutation (40 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
abnormal mitochondrial physiology ( J:344215 )
• aortic vascular smooth muscle (VSM) mitochondria show significantly lower maximal oxygen consumption and spare respiratory capacity, similar to what is observed in mice double homozygous for Wnt16tm2a(EUCOMM)Wtsi and Ldlrtm1Her

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory