Phenotypes Associated with This Genotype

Genotype
MGI:7779933

• Allelic Composition: Gigyf1^em1Xio/Gigyf1^em1Xio; Neurod6^tm1(cre)Kan/Neurod6⁺
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal short-term spatial reference memory ( J:335507 )

♂ • mice show a minor deficit in short-term memory in the T-maze test

decreased social novelty preference ( J:335507 )

♂ • mice have normal sociability during a social interaction session but show a deficit in the social novelty test, with reduced ability to discriminate novel and familiar conspecifics and impaired social memory

increased grooming behavior ( J:335507 )

♂ • mice exhibit repetitive behavior with excessive grooming

♂ • however, mice do not show changes in the open field, novel object recognition, rearing, marble burying, elevated plus maze, or fear conditioning tests

impaired social recognition ( J:335507 )

♂ • mice have normal sociability during a social interaction session but show a deficit in the social novelty test, with reduced ability to discriminate novel and familiar conspecifics and impaired social memory