Phenotypes Associated with This Genotype

Genotype
MGI:7779931

• Allelic Composition: Gigyf1^em1.1Xio/Gigyf1⁺
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

decreased social novelty preference ( J:335507 )

♂ • mice have normal sociability during a social interaction session but show a deficit in the social novelty test, with an inability to discriminate novel and familiar conspecifics and impaired social memory

♂ • however, no differences in anxiety in the open field, novel object recognition, rearing, marble burying, T-maze or elevated plus maze are seen

increased grooming behavior ( J:335507 )

♂ • mice exhibit repetitive behavior with excessive grooming

decreased locomotor activity ( J:335507 )

♂ • locomotion activity is slightly decreased in the open field

impaired social recognition ( J:335507 )

♂ • mice have normal sociability during a social interaction session but show a deficit in the social novelty test, with an inability to discriminate novel and familiar conspecifics and impaired social memory

nervous system

abnormal neuron morphology ( J:335507 )

♂ • mice exhibit a higher percentage of Slc17a7+ (Vglut1+) excitatory neurons in the CA2-CA3 region

abnormal glutaminergic neuron morphology ( J:335507 )

♂ • density of NeuN+ neurons in the CA2 region is increased, indicating increased CA2 glutamatergic neurons

♂ • however, synapse density is normal