Phenotypes Associated with This Genotype

Genotype
MGI:7767867

• Allelic Composition: Trim71^em1Ktka/Trim71^em1Ktka
• Genetic Background: C57BL/6J-Trim71^em1Ktka

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:335575 )

• embryonic lethality, with embryonic resorption by E13.5

nervous system

premature neuronal precursor differentiation ( J:335575 )

• gene expression analysis indicates premature neural differentiation of embryonic stem cells

abnormal embryonic neuroepithelium morphology ( J:335575 )

• E9.5 neuroepithelia of embryos has fewer pH3+ cells (cell proliferation marker) and more DCX+ cells (marker of immature neurons)

exencephaly ( J:335575 )

• mice exhibit completely penetrant exencephaly

decreased embryonic neuroepithelial cell proliferation ( J:335575 )

• E9.5 neuroepithelia of embryos has fewer pH3+ cells, indicating decreased cell proliferation

decreased neuronal stem cell self-renewal ( J:335575 )

• embryonic stem cells are less proliferative than wild-type stem cells upon N2B27-induced neural differentiation

cellular

premature neuronal precursor differentiation ( J:335575 )

• gene expression analysis indicates premature neural differentiation of embryonic stem cells

embryo

abnormal embryonic neuroepithelium morphology ( J:335575 )

• E9.5 neuroepithelia of embryos has fewer pH3+ cells (cell proliferation marker) and more DCX+ cells (marker of immature neurons)