Phenotypes for Doc2a Doc2b Doc2g Rph3a Syt7 MGI:7738542 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Doc2a^tm1Ytk/Doc2a^tm1Ytk Doc2b^tm1Aljg/Doc2b^tm1Aljg Doc2g^tm1.2Aljg/Doc2g^tm1.2Aljg Rph3a^tm1Sud/Rph3a^tm1Sud Syt7^tm1Sud/Syt7^tm1Sud
Genetic Background	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Doc2a^tm1Ytk mutation (0 available); any Doc2a mutation (15 available)
Doc2b^tm1Aljg mutation (0 available); any Doc2b mutation (20 available)
Doc2g^tm1.2Aljg mutation (0 available); any Doc2g mutation (11 available)
Rph3a^tm1Sud mutation (1 available); any Rph3a mutation (41 available)
Syt7^tm1Sud mutation (1 available); any Syt7 mutation (41 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal synaptic plasticity ( J:317639 )

• short-term plasticity is altered by accentuating short-term depression

abnormal synaptic depression ( J:317639 )

• hippocampal neurons show more pronounced short-term depression

• the deeper short-term depression is not associated with changes in evoked release during burst stimuli

decreased paired-pulse ratio ( J:317639 )

• hippocampal neurons show reduced paired-pulse ratio with a more pronounced short-term depression

• however, spontaneous neurotransmitter release in glutamatergic hippocampal neurons is unaltered

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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