Phenotypes for Gemin6 MGI:7720277 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Gemin6^em1(IMPC)Bay/Gemin6^em1(IMPC)Bay
Genetic Background	C57BL/6N-Gemin6^em1(IMPC)Bay/Mmmh

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gemin6^em1(IMPC)Bay mutation (1 available); any Gemin6 mutation (30 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Gemin6^em1(IMPC)Bay/Gemin6^em1(IMPC)Bay mice exhibit embryonic lethality, with embryos recovered at E3.5 as early blastocysts but not at E7.5. Blastocysts hatch from the zona pellucida and form outgrowths in culture.

mortality/aging

embryonic lethality between implantation and somite formation, complete penetrance ( J:279207 )

• homozygous embryos are present in expected Mendelian ratios at E3.5 and appear as early blastocysts; no homozygous embryos are recovered at E7.5 but excess resorption sites suggest that embryos elicit a decidual response in vivo

• in vitro, blastocysts hatch from the zona pellucida and form outgrowths after 3 days in culture

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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