Analysis Tools
cardiovascular system
| N |
• systolic blood pressure is normal and mice do not exhibit altered vascular function; isometric tension studies in isolated aortas show that vasoconstriction response to phenylephrine is normal, response to L-NAME is not altered, and endothelial cell-dependent relaxation to acetylcholine is not impacted and no difference is seen in the endothelial cell-independent dilation to sodium nitroprusside
|
|
• mice show a small, but significant, increase in heart rate compared to single mutant Apoe homozygotes
|
