Phenotypes Associated with This Genotype

Genotype
MGI:7712849

• Allelic Composition: Mir582^em1Minz/Mir582^em1Minz
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal postnatal subventricular zone morphology ( J:325358 )

• the number of neural stem cells (type-B cells) and transient amplifying progenitors (type-C cells) in the subventricular zone are reduced in 8-week-old mice, while the number of DCX+ neuroblasts (type-A cells) are increased, indicating enhanced neurogenesis

• the number of Ki67+ cells in the subventricular zone is increased

• however, no difference in the number of CD24+ ependymal cells

abnormal neuronal stem cell morphology ( J:325358 )

• the number of neural stem cells in the subventricular zone region is decreased

abnormal neuronal precursor cell number ( J:325358 )

• number of neural DCX+ neuroblasts is increased in the subventricular zone of 8-week-old mice

decreased neuronal stem cell self-renewal ( J:325358 )

• stemness of neural stem cells is decreased in the subventricular zone