Phenotypes Associated with This Genotype

Genotype
MGI:7662409

• Allelic Composition: Cdk5rap2^em1Mama/Cdk5rap2^em1Mama
• Genetic Background: involves: C57BL/6 * C57BL/6J * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

decreased brain weight ( J:310617 )

• decrease in brain weight and skull volume at P30

abnormal neocortex morphology ( J:310617 )

• cortical thickness is reduced in E14.5 and P30 neocortices

reproductive system

abnormal male germ cell physiology ( J:310617 )

♂ • reduction in maturation of germ cells in the testis

vision/eye

abnormal retina development ( J:310617 )

• defect in retinal development

microphthalmia ( J:310617 )

cellular

cellular phenotype ( J:310617 )

N • mouse embryonic fibroblasts (MEFs) do not present significant centrosome duplication defects

abnormal male germ cell physiology ( J:310617 )

♂ • reduction in maturation of germ cells in the testis