Phenotypes Associated with This Genotype

Genotype
MGI:7659221

• Allelic Composition: Il11^tm2.1Moto/Il11^tm2.1Moto; Tg(BGLAP-cre)1Clem/0
• Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj * FVB/NJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

adipose tissue

increased white adipose tissue amount ( J:345337 )

• adipose tissue area is increased in mice fed either regular diet or high-fat diet but is larger in mice under high-fat diet than under regular diet

• treatment with WAY-262611, a beta-catenin agonist and Dkk1 inhibitor, reduces adipose tissue area

homeostasis/metabolism

decreased circulating osteocalcin level ( J:345337 )

• serum osteocalcin levels are reduced

abnormal circulating interleukin level ( J:345337 )

• serum IL-11 levels are reduced

impaired glucose tolerance ( J:345337 )

• mice develop glucose intolerance, showing increased blood glucose after glucose loading by oral glucose tolerance test under both regular diet and high-fat diet

insulin resistance ( J:345337 )

• mice develop insulin resistance, showing increased fasting level of serum insulin in an oral glucose tolerance test

• homeostasis model assessment of insulin resistance (HOMA-IR) is increased under regular diet and high-fat diet

immune system

abnormal circulating interleukin level ( J:345337 )

• serum IL-11 levels are reduced

skeleton

decreased bone mineral density ( J:345337 )

• decrease in cortical and cancellous bone mineral density

decreased bone mass ( J:345337 )

abnormal ossification involved in bone remodeling ( J:345337 )

• while mechanical unloading reduces vertebral cancellous bone marrow density as in controls, mechanical reloading shows a lower increase in bone marrow density than seen in controls