Analysis Tools
hematopoietic system
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• upon activation with anti-CD3/CD28, CD8+ T cells from the spleen fail to proliferate leading to an effector memory CD8+ T cell impairment
• addition of cytidine to the culture medium during the activation rescues the proliferation defect of the CD8+ T cells
• however, no phenotypic differences are seen in the thymus and spleen, and no abnormalities are detected in blood, spleen cellularity and cell type composition
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immune system
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• upon activation with anti-CD3/CD28, CD8+ T cells from the spleen fail to proliferate leading to an effector memory CD8+ T cell impairment
• addition of cytidine to the culture medium during the activation rescues the proliferation defect of the CD8+ T cells
• however, no phenotypic differences are seen in the thymus and spleen, and no abnormalities are detected in blood, spleen cellularity and cell type composition
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cellular
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• upon activation with anti-CD3/CD28, CD8+ T cells from the spleen fail to proliferate leading to an effector memory CD8+ T cell impairment
• addition of cytidine to the culture medium during the activation rescues the proliferation defect of the CD8+ T cells
• however, no phenotypic differences are seen in the thymus and spleen, and no abnormalities are detected in blood, spleen cellularity and cell type composition
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