Analysis Tools
hematopoietic system
| N |
• normal numbers of splenic immature B cells
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• in a mixed bone marrow competitive chimera the number of Fo and MZ cells derived from null mice are reduced by 47% and 59%, respectively
• in culture the proliferation index is reduced to 1 compared to 3 in control cells
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• 7 days after immunization with 4-hydroxy-3-nitrophenyl-acetyl conjugated to keyhole limpet hemocyanin germinal center B cells are almost completely absent with a 10-fold reduction compared to similarly treated control mice
• light zone and dark zone germinal center B cells are reduced by 9-fold and 15-fold, respectively
• reduction in B cells corresponds to a greater than 100-fold reduction in NP-specific IgG1 antibody secreting cells in the spleen
• remaining B cells have only a 40% reduction in EIF4A1
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• decrease in both low- and high-affinity IgG1 antibodies following immunization
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cellular
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• in a mixed bone marrow competitive chimera the number of Fo and MZ cells derived from null mice are reduced by 47% and 59%, respectively
• in culture the proliferation index is reduced to 1 compared to 3 in control cells
|
immune system
|
• in a mixed bone marrow competitive chimera the number of Fo and MZ cells derived from null mice are reduced by 47% and 59%, respectively
• in culture the proliferation index is reduced to 1 compared to 3 in control cells
|
|
• 7 days after immunization with 4-hydroxy-3-nitrophenyl-acetyl conjugated to keyhole limpet hemocyanin germinal center B cells are almost completely absent with a 10-fold reduction compared to similarly treated control mice
• light zone and dark zone germinal center B cells are reduced by 9-fold and 15-fold, respectively
• reduction in B cells corresponds to a greater than 100-fold reduction in NP-specific IgG1 antibody secreting cells in the spleen
• remaining B cells have only a 40% reduction in EIF4A1
|
|
• decrease in both low- and high-affinity IgG1 antibodies following immunization
|
