Phenotypes Associated with This Genotype

Genotype
MGI:7645413

• Allelic Composition: Gt(ROSA)26Sor^{em1(Tbc1d15)Jren}/Gt(ROSA)26Sor^{em1(Tbc1d15)Jren}; A1cf^{Tg(Myh6-cre/Esr1*)1Jmk}/A1cf⁺
• Genetic Background: involves: C57BL/6N * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

decreased susceptibility to myocardial ischemic injury ( J:341775 )

♂ • cardiac dysfunction is reduced following ischemia/reperfusion injury

♂ • decrease in adverse cardiac remodeling (interstitial fibrosis) following ischemia/reperfusion injury

♂ • decrease in mitochondrial damage following ischemia/reperfusion injury

decreased myocardial infarct size ( J:341775 )

♂ • following ischemia/reperfusion injury

cellular

abnormal mitochondrial physiology ( J:341775 )

♂ • resistance to ischemia/reperfusion induced injury in cardiac cells

♂ • ischemia/reperfusion induced increase in tethering of mitochondria and lysosomes is reduced

homeostasis/metabolism

decreased susceptibility to myocardial ischemic injury ( J:341775 )

♂ • cardiac dysfunction is reduced following ischemia/reperfusion injury

♂ • decrease in adverse cardiac remodeling (interstitial fibrosis) following ischemia/reperfusion injury

♂ • decrease in mitochondrial damage following ischemia/reperfusion injury

decreased myocardial infarct size ( J:341775 )

♂ • following ischemia/reperfusion injury